Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents
Joint Authors
Silva, Simone Rodrigues
Duarte, Érica Correia
Ramos, Guilherme Santos
Kock, Flávio Vinícius Crizóstomo
Andrade, Fabiana Diuk
Colnago, Luiz Alberto
Demicheli, Cynthia
Frézard, Frédéric
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Complexes of gadolinium(III) with N-octanoyl-N-methylglucamine (L8) and N-decanoyl-N-methylglucamine (L10) with 1 : 2 stoichiometry were synthesized and characterized by elemental analysis, electrospray ionization-tandem mass spectrometry (ESI-MS), infrared (IR) spectroscopy, and molar conductivity measurements.
The transverse ( r 2 ) and longitudinal ( r 1 ) relaxivity protons were measured at 20 MHz and compared with those of the commercial contrasts.
These complexes were incorporated in liposomes, resulting in the increase of the vesicle zeta potential.
Both the free and liposome-incorporated gadolinium complexes showed high relaxation effectiveness, compared to commercial contrast agent gadopentetate dimeglumine (Magnevist).
The high relaxivity of these complexes was attributed to the molecular rotation that occurs more slowly, because of the elevated molecular weight and incorporation in liposomes.
The results establish that these paramagnetic complexes are highly potent contrast agents, making them excellent candidates for various applications in molecular MR imaging.
American Psychological Association (APA)
Silva, Simone Rodrigues& Duarte, Érica Correia& Ramos, Guilherme Santos& Kock, Flávio Vinícius Crizóstomo& Andrade, Fabiana Diuk& Frézard, Frédéric…[et al.]. 2015. Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents. Bioinorganic Chemistry and Applications،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054064
Modern Language Association (MLA)
Silva, Simone Rodrigues…[et al.]. Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents. Bioinorganic Chemistry and Applications No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054064
American Medical Association (AMA)
Silva, Simone Rodrigues& Duarte, Érica Correia& Ramos, Guilherme Santos& Kock, Flávio Vinícius Crizóstomo& Andrade, Fabiana Diuk& Frézard, Frédéric…[et al.]. Gadolinium(III) Complexes with N-Alkyl-N-methylglucamine Surfactants Incorporated into Liposomes as Potential MRI Contrast Agents. Bioinorganic Chemistry and Applications. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054064