PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
Joint Authors
Monserrat, José María
Dal Bosco, Lidiane
Weber, Gisele E. B.
Parfitt, Gustavo M.
Paese, Karina
Gonçalves, Carla O. F.
Serodre, Tiago M.
Furtado, Clascídia A.
Santos, Adelina P.
Barros, Daniela M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Carbon nanotubes (CNT) are promising materials for biomedical applications, especially in the field of neuroscience; therefore, it is essential to evaluate the neurotoxicity of these nanomaterials.
The present work assessed the effects of single-walled CNT functionalized with polyethylene glycol (SWCNT-PEG) on the consolidation and retrieval of contextual fear memory in rats and on oxidative stress parameters in the hippocampus.
SWCNT-PEG were dispersed in water at concentrations of 0.5, 1.0, and 2.1 mg/mL and infused into the rat hippocampus.
The infusion was completed immediately after training and 30 min before testing of a contextual fear conditioning task, resulting in exposure times of 24 h and 30 min, respectively.
The results showed that a short exposure to SWCNT-PEG impaired fear memory retrieval and caused lipid peroxidation in the hippocampus.
This response was transient and overcome by the mobilization of antioxidant defenses at 24 h.
These effects occurred at low and intermediate but not high concentration of SWCNT-PEG, suggesting that the observed biological response may be related to the concentration-dependent increase in particle size in SWCNT-PEG dispersions.
American Psychological Association (APA)
Dal Bosco, Lidiane& Weber, Gisele E. B.& Parfitt, Gustavo M.& Paese, Karina& Gonçalves, Carla O. F.& Serodre, Tiago M.…[et al.]. 2015. PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054231
Modern Language Association (MLA)
Dal Bosco, Lidiane…[et al.]. PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054231
American Medical Association (AMA)
Dal Bosco, Lidiane& Weber, Gisele E. B.& Parfitt, Gustavo M.& Paese, Karina& Gonçalves, Carla O. F.& Serodre, Tiago M.…[et al.]. PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054231