Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future
Joint Authors
Granato, Marisa
Santarelli, Roberta
Gonnella, Roberta
Farina, Antonella
Trivedi, Pankaj
Faggioni, Alberto
Cirone, Mara
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Constitutively activated prosurvival pathways render cancer cells addicted to their effects.
Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy.
Primary effusion lymphomas (PELs) are very aggressive non-Hodgkin’s B cell lymphomas, whose pathogenesis is strictly linked to Kaposi’s sarcoma herpesvirus (KSHV) infection.
Here we summarized previous studies from our and other laboratories exploring the cytotoxic effect of drugs inhibiting the main prosurvival pathways activated in PEL cells.
Moreover, the immunogenicity of cell death, in terms of dendritic cell (DC) activation and their potential side effect on DCs, is discussed.
American Psychological Association (APA)
Granato, Marisa& Santarelli, Roberta& Gonnella, Roberta& Farina, Antonella& Trivedi, Pankaj& Faggioni, Alberto…[et al.]. 2015. Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054234
Modern Language Association (MLA)
Granato, Marisa…[et al.]. Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054234
American Medical Association (AMA)
Granato, Marisa& Santarelli, Roberta& Gonnella, Roberta& Farina, Antonella& Trivedi, Pankaj& Faggioni, Alberto…[et al.]. Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054234