Effects of Pregnancy and Lactation on Iron Metabolism in Rats
Joint Authors
Gao, Guofen
Liu, Shang-Yuan
Wang, Hui-Jie
Zhang, Tian-Wei
Yu, Peng
Duan, Xiang-Lin
Zhao, Shu-E
Chang, Yan-Zhong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In female, inadequate iron supply is a highly prevalent problem that often leads to iron-deficiency anemia.
This study aimed to understand the effects of pregnancy and lactation on iron metabolism.
Rats with different days of gestation and lactation were used to determine the variations in iron stores and serum iron level and the changes in expression of iron metabolism-related proteins, including ferritin, ferroportin 1 (FPN1), ceruloplasmin (Cp), divalent metal transporter 1 (DMT1), transferrin receptor 1 (TfR1), and the major iron-regulatory molecule—hepcidin.
We found that iron stores decline dramatically at late-pregnancy period, and the low iron store status persists throughout the lactation period.
The significantly increased FPN1 level in small intestine facilitates digestive iron absorption, which maintains the serum iron concentration at a near-normal level to meet the increase of iron requirements.
Moreover, a significant decrease of hepcidin expression is observed during late-pregnancy and early-lactation stages, suggesting the important regulatory role that hepcidin plays in iron metabolism during pregnancy and lactation.
These results are fundamental to the understanding of iron homeostasis during pregnancy and lactation and may provide experimental bases for future studies to identify key molecules expressed during these special periods that regulate the expression of hepcidin, to eventually improve the iron-deficiency status.
American Psychological Association (APA)
Gao, Guofen& Liu, Shang-Yuan& Wang, Hui-Jie& Zhang, Tian-Wei& Yu, Peng& Duan, Xiang-Lin…[et al.]. 2015. Effects of Pregnancy and Lactation on Iron Metabolism in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054235
Modern Language Association (MLA)
Gao, Guofen…[et al.]. Effects of Pregnancy and Lactation on Iron Metabolism in Rats. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054235
American Medical Association (AMA)
Gao, Guofen& Liu, Shang-Yuan& Wang, Hui-Jie& Zhang, Tian-Wei& Yu, Peng& Duan, Xiang-Lin…[et al.]. Effects of Pregnancy and Lactation on Iron Metabolism in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054235