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Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway
Joint Authors
Zhao, Yupeng
Chen, Kaizheng
Shen, Xia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sevoflurane is the most widely used inhaled anesthetic.
Environmental enrichment (EE) can reverse sevoflurane-induced learning and memory impairment in young mice.
However, the mechanism by which EE elicits this effect is unclear.
The peroxisome proliferator-activated receptor (PPAR) regulatory pathway plays a critical role in the regulation of inflammation in central nervous system diseases.
In this study, we investigated whether EE attenuates sevoflurane-induced learning and memory disability via the PPAR signaling pathway.
Six-day-old mice were treated with 3% sevoflurane for 2 hours daily from postnatal day 6 (P6) to P8.
Then, the mice were treated with EE.
The effects of sevoflurane on learning and memory function, PPAR-γ expression in the brain, and the numbers of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells and 5-bromodeoxyuridine-positive cells in the hippocampus were determined.
Sevoflurane induced neuronal apoptosis and neurogenesis inhibition, which may impair learning and memory in young mice.
Furthermore, sevoflurane downregulated PPAR-γ expression.
Both EE and the PPAR-γ agonist, rosiglitazone, attenuated sevoflurane-induced neuronal apoptosis, neurogenesis inhibition, and learning and memory impairment.
Our findings suggest that EE ameliorated sevoflurane-induced neurotoxicity and learning and memory impairment through the PPAR-γ signaling pathway.
PPAR-γ may be a potential therapeutic target for preventing or treating sevoflurane-induced neurotoxicity.
American Psychological Association (APA)
Zhao, Yupeng& Chen, Kaizheng& Shen, Xia. 2015. Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054241
Modern Language Association (MLA)
Zhao, Yupeng…[et al.]. Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054241
American Medical Association (AMA)
Zhao, Yupeng& Chen, Kaizheng& Shen, Xia. Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054241