Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer
Joint Authors
Lv, Wenjie
Wang, Lei
Lu, Jianhua
Mu, Jiasheng
Liu, Yingbin
Dong, Ping
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Gallbladder cancer (GBC) is one of the mostly aggressive diseases with poor prognosis due to the lack of severe symptoms.
To date, little is known about the potential roles and underlying mechanisms of long noncoding RNAs (lncRNAs) in GBC initiation and progression.
Thus, it provides us with a novel insight into the contribution of lncRNAs to GBC development.
Remarkably, we found the differential expression of a lncRNA, namely, KIAA0125, in a pair of GBC cell sublines which possess different metastatic potentials.
Then the effects of KIAA0125 on GBC cell migration, invasion, and epithelial-mesenchymal transitions (EMT) were investigated by using a lentivirus-mediated RNA interference (RNAi) system.
Notably, cell migration and invasion were strongly inhibited by KIAA0125 suppression.
Moreover, the expression of β-Catenin was increased and the expression of Vimentin was decreased in GBC-SD/M cells after KIAA0125 knockdown.
Thus, our findings suggested that KIAA0125 promoted the migration and invasion of GBC cells and could serve as a potential therapeutic target in advanced GBC.
American Psychological Association (APA)
Lv, Wenjie& Wang, Lei& Lu, Jianhua& Mu, Jiasheng& Liu, Yingbin& Dong, Ping. 2015. Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054242
Modern Language Association (MLA)
Lv, Wenjie…[et al.]. Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054242
American Medical Association (AMA)
Lv, Wenjie& Wang, Lei& Lu, Jianhua& Mu, Jiasheng& Liu, Yingbin& Dong, Ping. Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054242