MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges
Joint Authors
Lu, Haiqi
Jin, Hongchuan
Lan, Huiyin
Wang, Xian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are a group of small noncoding RNAs (ncRNAs) that posttranscriptionally regulate gene expression by targeting their corresponding messenger RNAs (mRNAs).
Dysregulated miRNAs have been considered as a new type of ‘‘oncomiRs’’ or ‘‘tumor suppressors,” playing essential roles in cancer initiation and progression.
Using genome-wide detection methods, ubiquitously aberrant expression profiles of miRNAs have been identified in a broad array of human cancers, showing great potential as novel diagnostic and prognostic biomarkers of cancer with high specificity and sensitivity.
The detectable miRNAs in tissue, blood, and other body fluids with high stability provide an abundant source for miRNA-based biomarkers in human cancers.
Despite the fact that an increasing number of potential miRNA biomarkers have been reported, the transition of miRNAs-based biomarkers from bench to bedside still necessitates addressing several challenges.
In this review, we will summarize our current understanding of miRNAs as potential biomarkers in human cancers.
American Psychological Association (APA)
Lan, Huiyin& Lu, Haiqi& Wang, Xian& Jin, Hongchuan. 2015. MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1054267
Modern Language Association (MLA)
Lan, Huiyin…[et al.]. MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1054267
American Medical Association (AMA)
Lan, Huiyin& Lu, Haiqi& Wang, Xian& Jin, Hongchuan. MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1054267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054267