Effects of High Volume Haemodiafiltration on Inflammatory Response Profile and Microcirculation in Patients with Septic Shock
Joint Authors
Kern, H.
Starkopf, Joel
Maddison, Liivi
Tamme, Kadri
Kruusat, Rein
Ehrlich, Hans-Erik
Viirelaid, Mirjam
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
High volumes of haemofiltration are used in septic patients to control systemic inflammation and improve patient outcomes.
We aimed to clarify if extended intermittent high volume online haemodiafiltration (HVHDF) influences patient haemodynamics and cytokines profile and/or has effect upon sublingual microcirculation in critically ill septic shock patients.
Methods.
Main haemodynamic and clinical variables and concentrations of cytokines were evaluated before and after HVHDF in 19 patients with septic shock requiring renal replacement therapy due to acute kidney injury.
Sublingual microcirculation was assessed in 9 patients.
Results.
The mean (SD) time of HVHDF was 9.4 (1.8) hours.
The median convective volume was 123 mL/kg/h.
The mean (SD) dose of norepinephrine required to maintain mean arterial pressure at the target range of 70–80 mmHg decreased from 0.40 (0.43) μg/kg/min to 0.28 (0.33) μg/kg/min (p = 0.009).
No significant changes in the measured cytokines or microcirculatory parameters were observed before and after HVHDF.
Conclusions.
The single-centre study suggests that extended HVHDF results in decrease of norepinephrine requirement in patients with septic shock.
Haemodynamic improvement was not associated with decrease in circulating cytokine levels, and sublingual microcirculation was well preserved.
American Psychological Association (APA)
Tamme, Kadri& Maddison, Liivi& Kruusat, Rein& Ehrlich, Hans-Erik& Viirelaid, Mirjam& Kern, H.…[et al.]. 2015. Effects of High Volume Haemodiafiltration on Inflammatory Response Profile and Microcirculation in Patients with Septic Shock. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054270
Modern Language Association (MLA)
Tamme, Kadri…[et al.]. Effects of High Volume Haemodiafiltration on Inflammatory Response Profile and Microcirculation in Patients with Septic Shock. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054270
American Medical Association (AMA)
Tamme, Kadri& Maddison, Liivi& Kruusat, Rein& Ehrlich, Hans-Erik& Viirelaid, Mirjam& Kern, H.…[et al.]. Effects of High Volume Haemodiafiltration on Inflammatory Response Profile and Microcirculation in Patients with Septic Shock. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054270