Aqueous Cytokines as Predictors of Macular Edema in Patients with Diabetes following Uncomplicated Phacoemulsification Cataract Surgery
Joint Authors
Dong, Ning
Xu, Bing
Wang, Bingsong
Chu, Liqun
Tang, Xin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aims to ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in diabetic patients following uncomplicated phacoemulsification cataract surgery.
Undiluted aqueous humor samples were obtained from 136 consecutive type 2 diabetic patients who underwent cataract surgery.
The concentrations of 27 cytokines were measured in aqueous humor using the multiplex bead immunoassay.
At the final follow-up examination, 116 patients completed 4 weeks of follow-up, and the incidence of macular edema was 29.31% (34 patients) 4 weeks after cataract surgery.
Compared to the ME (−) patients, the concentrations of interleukin-1β (IL-1β) ( P < 0.001 ), IL-6 ( P < 0.001 ), IL-8 ( P < 0.001 ), interferon-induced protein-10 (IP-10) ( P = 0.003 ), monocyte chemotactic protein-1 (MCP-1) ( P < 0.001 ), and vascular endothelial growth factor (VEGF) ( P < 0.001 ) in the ME (+) patients were significantly higher.
In addition, the aqueous levels of IL-1β ( r = 0.288 ), IL-6 ( r = 0.345 ), IL-8 ( r = 0.256 ), IP-10 ( r = 0.377 ), MCP-1 ( r = 0.423 ), and VEGF ( r = 0.279 ) were positively correlated with the postoperative foveal center point thickness (FCPT).
However, the aqueous levels of IL-10 ( P = 0.003 ) and IL-12 ( P = 0.017 ) were significantly lower in patients with ME.
These results suggest IL-1β, IL-6, IL-8, IL-10, IL-12, IP-10, MCP-1, and VEGF may be potential predictors of postoperative macular thickness in patients with diabetes following uncomplicated phacoemulsification cataract surgery.
American Psychological Association (APA)
Dong, Ning& Xu, Bing& Wang, Bingsong& Chu, Liqun& Tang, Xin. 2015. Aqueous Cytokines as Predictors of Macular Edema in Patients with Diabetes following Uncomplicated Phacoemulsification Cataract Surgery. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054276
Modern Language Association (MLA)
Dong, Ning…[et al.]. Aqueous Cytokines as Predictors of Macular Edema in Patients with Diabetes following Uncomplicated Phacoemulsification Cataract Surgery. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054276
American Medical Association (AMA)
Dong, Ning& Xu, Bing& Wang, Bingsong& Chu, Liqun& Tang, Xin. Aqueous Cytokines as Predictors of Macular Edema in Patients with Diabetes following Uncomplicated Phacoemulsification Cataract Surgery. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054276