Relationship between Hyperuricemia and Lipid Profiles in US Adults
Joint Authors
Chen, Wei-Liang
Peng, Tao-Chun
Wang, Chung-Ching
Kao, Tung-Wei
Chan, James Yi-Hsin
Yang, Ya-Hui
Chang, Yaw-Wen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Although the link between hyperuricemia and metabolic syndrome had been recognized, the association of the dyslipidemia among individuals with hyperuricemia remains not comprehensively assessed.
Methods.
Using NHANES III study, we examined the relation between serum lipid profiles and different serum uric acid levels, including serum total cholesterol, LDL cholesterol, triglycerides, HDL cholesterol, apolipoprotein-B, lipoprotein (a), apolipoprotein AI, ratio of triglycerides to HDL cholesterol, and ratio of apolipoprotein-B to AI.
Results.
After adjusting for potential confounders, average differences (95% confidence interval) comparing the top to the bottom (reference) serum uric acid were 0.29 (0.19, 0.39) mmol/L for total cholesterol, 0.33 (0.26, 0.41) mmol/L for triglycerides, 0.14 (0.01, 0.27) mmol/L for LDL cholesterol, −0.08 (−0.11, −0.05) mmol/L for HDL, and 0.09 (0.05, 0.12) g/L for serum apolipoprotein-B.
Notably, ratios of triglycerides to HDL cholesterol and apolipoprotein-B to AI were also linearly associated with uric acid levels (P for trend < 0.001).
Conclusions.
This study suggested that serum LDL cholesterol,triglycerides, total cholesterol, apolipoprotein-B levels, ratio of triglycerides to HDL cholesterol, and ratio of apolipoprotein-B to AI are strongly associated with serum uric acid levels, whereas serum HDL cholesterol levels are significantly inversely associated.
In the clinical practice, the more comprehensive strategic management to deal with dyslipidemia and hyperuricemia deserves further investigation.
American Psychological Association (APA)
Peng, Tao-Chun& Wang, Chung-Ching& Kao, Tung-Wei& Chan, James Yi-Hsin& Yang, Ya-Hui& Chang, Yaw-Wen…[et al.]. 2015. Relationship between Hyperuricemia and Lipid Profiles in US Adults. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054278
Modern Language Association (MLA)
Peng, Tao-Chun…[et al.]. Relationship between Hyperuricemia and Lipid Profiles in US Adults. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054278
American Medical Association (AMA)
Peng, Tao-Chun& Wang, Chung-Ching& Kao, Tung-Wei& Chan, James Yi-Hsin& Yang, Ya-Hui& Chang, Yaw-Wen…[et al.]. Relationship between Hyperuricemia and Lipid Profiles in US Adults. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054278