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Dichloroacetate Decreases Cell Health and Activates Oxidative Stress Defense Pathways in Rat Alveolar Type II Pneumocytes
Joint Authors
Valauri-Orton, Alexis
Bschorer, Frizzi
Bernd, Karen K.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Dichloroacetate (DCA) is a water purification byproduct that is known to be hepatotoxic and hepatocarcinogenic and to induce peripheral neuropathy and damage macrophages.
This study characterizes the effects of the haloacetate on lung cells by exposing rat alveolar type II (L2) cells to 0–24 mM DCA for 6–24 hours.
Increasing DCA concentration and the combination of increasing DCA concentration plus longer exposures decrease measures of cellular health.
Length of exposure has no effect on oxidative stress biomarkers, glutathione, SOD, or CAT.
Increasing DCA concentration alone does not affect total glutathione or its redox ratio but does increase activity in the SOD/CAT oxidative stress defense pathway.
These data suggest that alveolar type II cells rely on SOD and CAT more than glutathione to combat DCA-induced stress.
American Psychological Association (APA)
Valauri-Orton, Alexis& Bschorer, Frizzi& Bernd, Karen K.. 2015. Dichloroacetate Decreases Cell Health and Activates Oxidative Stress Defense Pathways in Rat Alveolar Type II Pneumocytes. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054285
Modern Language Association (MLA)
Valauri-Orton, Alexis…[et al.]. Dichloroacetate Decreases Cell Health and Activates Oxidative Stress Defense Pathways in Rat Alveolar Type II Pneumocytes. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054285
American Medical Association (AMA)
Valauri-Orton, Alexis& Bschorer, Frizzi& Bernd, Karen K.. Dichloroacetate Decreases Cell Health and Activates Oxidative Stress Defense Pathways in Rat Alveolar Type II Pneumocytes. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054285