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In Vivo Targeted Magnetic Resonance Imaging of Endogenous Neural Stem Cells in the Adult Rodent Brain
Joint Authors
Zhong, Xiao-Mei
Zhang, Fang
Wen, Xue-Hua
Zhang, Xiang
Duan, Xiao-Hui
Shen, Jun
Yang, Ming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Neural stem cells in the adult mammalian brain have a significant level of neurogenesis plasticity.
In vivo monitoring of adult endogenous NSCs would be of great benefit to the understanding of the neurogenesis plasticity under normal and pathological conditions.
Here we show the feasibility of in vivo targeted MR imaging of endogenous NSCs in adult mouse brain by intraventricular delivery of monoclonal anti-CD15 antibody conjugated superparamagnetic iron oxide nanoparticles.
After intraventricular administration of these nanoparticles, the subpopulation of NSCs in the anterior subventricular zone and the beginning of the rostral migratory stream could be in situ labeled and were in vivo visualized with 7.0-T MR imaging during a period from 1 day to 7 days after the injection.
Histology confirmed that the injected targeted nanoparticles were specifically bound to CD15 positive cells and their surrounding extracellular matrix.
Our results suggest that in vivo targeted MR imaging of endogenous neural stem cells in adult rodent brain could be achieved by using anti-CD15-SPIONs as the molecular probe; and this targeting imaging strategy has the advantage of a rapid in vivo monitoring of the subpopulation of endogenous NSCs in adult brains.
American Psychological Association (APA)
Zhong, Xiao-Mei& Zhang, Fang& Yang, Ming& Wen, Xue-Hua& Zhang, Xiang& Duan, Xiao-Hui…[et al.]. 2015. In Vivo Targeted Magnetic Resonance Imaging of Endogenous Neural Stem Cells in the Adult Rodent Brain. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054293
Modern Language Association (MLA)
Zhong, Xiao-Mei…[et al.]. In Vivo Targeted Magnetic Resonance Imaging of Endogenous Neural Stem Cells in the Adult Rodent Brain. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054293
American Medical Association (AMA)
Zhong, Xiao-Mei& Zhang, Fang& Yang, Ming& Wen, Xue-Hua& Zhang, Xiang& Duan, Xiao-Hui…[et al.]. In Vivo Targeted Magnetic Resonance Imaging of Endogenous Neural Stem Cells in the Adult Rodent Brain. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054293