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The Influence of Metabolic Factors for Nonalcoholic Fatty Liver Disease in Women
Joint Authors
Chung, Goh Eun
Yim, Jeong Yoon
Kim, Donghee
Lim, Seon Hee
Yang, Jong In
Kim, Young Sun
Yang, Sun Young
Kwak, Min-Sun
Kim, Joo Sung
Cho, Sang-Heon
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background/Aims.
Women after menopause have increased insulin resistance and visceral fat, which may increase the prevalence of nonalcoholic fatty liver disease (NAFLD).
However, the pathogenesis of NAFLD in women has not been clearly defined.
In this study, we aimed to determine the risk factors for NAFLD in women.
Methods.
A retrospective cohort study was conducted.
Women who underwent abdominal ultrasonography and blood sampling for routine health check-ups were recruited.
Results.
Among 1,423 subjects, 695 women (48.9%) were in a menopausal state.
The prevalence of NAFLD was higher in postmenopausal women than in premenopausal women (27.2% versus 14.4%, P<0.001).
In premenopausal women, low HDL-cholesterol, central obesity, and homeostasis model assessment-estimated insulin resistance showed a significant association with the increased risk of NAFLD in multivariate analysis.
In postmenopausal women, the presence of diabetes, triglyceridemia, and central obesity showed a significant association with the risk of NAFLD.
The presence of menopause and hormone replacement therapy in postmenopausal women were not risk factors for NAFLD.
Conclusions.
Our findings showed different metabolic factors for NAFLD in pre- and postmenopausal women.
However, the key issues are the same: central obesity and insulin resistance.
These results reemphasize the importance of metabolic factors irrespective of menopausal status in the pathogenesis of NAFLD in women.
American Psychological Association (APA)
Chung, Goh Eun& Yim, Jeong Yoon& Kim, Donghee& Lim, Seon Hee& Yang, Jong In& Kim, Young Sun…[et al.]. 2015. The Influence of Metabolic Factors for Nonalcoholic Fatty Liver Disease in Women. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054296
Modern Language Association (MLA)
Chung, Goh Eun…[et al.]. The Influence of Metabolic Factors for Nonalcoholic Fatty Liver Disease in Women. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054296
American Medical Association (AMA)
Chung, Goh Eun& Yim, Jeong Yoon& Kim, Donghee& Lim, Seon Hee& Yang, Jong In& Kim, Young Sun…[et al.]. The Influence of Metabolic Factors for Nonalcoholic Fatty Liver Disease in Women. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054296