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The Fine LINE: Methylation Drawing the Cancer Landscape
Joint Authors
Koturbash, Igor
Miousse, Isabelle R.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
LINE-1 (L1) is the most abundant mammalian transposable element that comprises nearly 20% of the genome, and nearly half of the mammalian genome has stemmed from L1-mediated mobilization.
Expression and retrotransposition of L1 are suppressed by complex mechanisms, where the key role belongs to DNA methylation.
Alterations in L1 methylation may lead to aberrant expression of L1 and have been described in numerous diseases.
Accumulating evidence clearly indicates that loss of global DNA methylation observed in cancer development and progression is tightly associated with hypomethylation of L1 elements.
Significant progress achieved in the last several years suggests that such parameters as L1 methylation status can be potentially utilized as clinical biomarkers for determination of the disease stage and in predicting the disease-free survival in cancer patients.
In this paper, we summarize the current knowledge on L1 methylation, with specific emphasis given to success and challenges on the way of introduction of L1 into clinical practice.
American Psychological Association (APA)
Miousse, Isabelle R.& Koturbash, Igor. 2015. The Fine LINE: Methylation Drawing the Cancer Landscape. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054297
Modern Language Association (MLA)
Miousse, Isabelle R.& Koturbash, Igor. The Fine LINE: Methylation Drawing the Cancer Landscape. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054297
American Medical Association (AMA)
Miousse, Isabelle R.& Koturbash, Igor. The Fine LINE: Methylation Drawing the Cancer Landscape. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054297