A Protective Role of Arecoline Hydrobromide in Experimentally Induced Male Diabetic Rats
Joint Authors
Saha, Indraneel
Das, Joydeep
Maiti, Biswaranjan
Chatterji, Urmi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objectives.
Arecoline, the most potent and abundant alkaloid of betel nut, causes elevation of serum testosterone and androgen receptor expression in rat prostate, in addition to increase in serum insulin levels in rats, leading to insulin resistance and type 2 diabetes-like conditions.
This study investigated the role of arecoline on the reproductive status of experimentally induced type 1 diabetic rats.
Methods.
Changes in the cellular architecture were analyzed by transmission electron microscopy.
Blood glucose, serum insulin, testosterone, FSH, and LH were assayed.
Fructose content of the coagulating gland and sialic acid content of the seminal vesicles were also analyzed.
Results.
Arecoline treatment for 10 days at a dose of 10 mg/kg of body weight markedly facilitated β-cell regeneration and reversed testicular and sex accessory dysfunctions by increasing the levels of serum insulin and gonadotropins in type 1 diabetic rats.
Critical genes related to β-cell regeneration, such as pancreatic and duodenal homeobox 1 (pdx-1) and glucose transporter 2 (GLUT-2), were found to be activated by arecoline at the protein level.
Conclusion.
It can thus be suggested that arecoline is effective in ameliorating the detrimental effects caused by insulin deficiency on gonadal and male sex accessories in rats with type 1 diabetes.
American Psychological Association (APA)
Saha, Indraneel& Das, Joydeep& Maiti, Biswaranjan& Chatterji, Urmi. 2015. A Protective Role of Arecoline Hydrobromide in Experimentally Induced Male Diabetic Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054321
Modern Language Association (MLA)
Saha, Indraneel…[et al.]. A Protective Role of Arecoline Hydrobromide in Experimentally Induced Male Diabetic Rats. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1054321
American Medical Association (AMA)
Saha, Indraneel& Das, Joydeep& Maiti, Biswaranjan& Chatterji, Urmi. A Protective Role of Arecoline Hydrobromide in Experimentally Induced Male Diabetic Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054321