Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation
Joint Authors
Sauma, Daniela
De Calisto, Jaime
Flores-Santibáñez, Felipe
Crisóstomo, Natalia
Fernández, Dominique
Mora, J. Rodrigo
Rosemblatt, Mario
Manríquez, Valeria
Tejón, Gabriela
Hidalgo, Yessia
Bono, María Rosa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Maintaining the identity of Foxp3+ regulatory T cells (Tregs) is critical for controlling immune responses in the gut, where an imbalance between Tregs and T effector cells has been linked to inflammatory bowel disease.
Accumulating evidence suggests that Tregs can convert into Th17 cells and acquire an inflammatory phenotype.
In this study, we used an adoptive transfer model of Ag-specific T cells to study the contribution of different factors to the reprogramming of in vitro-generated Treg cells (iTreg) into IL-17-producing cells in a mouse model of gut inflammation in vivo.
Our results show that intestinal inflammation induces the reprogramming of iTreg cells into IL-17-producing cells and that vitamin A restrains reprogramming in the gut.
We also demonstrate that the presence of IL-2 during the in vitro generation of iTreg cells confers resistance to Th17 conversion but that IL-2 and retinoic acid (RA) cooperate to maintain Foxp3 expression following stimulation under Th17-polarizing conditions.
Additionally, although IL-2 and RA differentially regulate the expression of different Treg cell suppressive markers, Treg cells generated under different polarizing conditions present similar suppressive capacity.
American Psychological Association (APA)
Tejón, Gabriela& Manríquez, Valeria& De Calisto, Jaime& Flores-Santibáñez, Felipe& Hidalgo, Yessia& Crisóstomo, Natalia…[et al.]. 2015. Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054329
Modern Language Association (MLA)
Tejón, Gabriela…[et al.]. Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054329
American Medical Association (AMA)
Tejón, Gabriela& Manríquez, Valeria& De Calisto, Jaime& Flores-Santibáñez, Felipe& Hidalgo, Yessia& Crisóstomo, Natalia…[et al.]. Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054329