Optimal Experiment Design for Monoexponential Model Fitting: Application to Apparent Diffusion Coefficient Imaging
Joint Authors
Alipoor, Mohammad
Maier, Stephan E.
Gu, Irene Yu-Hua
Mehnert, Andrew
Kahl, Fredrik
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The monoexponential model is widely used in quantitative biomedical imaging.
Notable applications include apparent diffusion coefficient (ADC) imaging and pharmacokinetics.
The application of ADC imaging to the detection of malignant tissue has in turn prompted several studies concerning optimal experiment design for monoexponential model fitting.
In this paper, we propose a new experiment design method that is based on minimizing the determinant of the covariance matrix of the estimated parameters (D-optimal design).
In contrast to previous methods, D-optimal design is independent of the imaged quantities.
Applying this method to ADC imaging, we demonstrate its steady performance for the whole range of input variables (imaged parameters, number of measurements, and range of b-values).
Using Monte Carlo simulations we show that the D-optimal design outperforms existing experiment design methods in terms of accuracy and precision of the estimated parameters.
American Psychological Association (APA)
Alipoor, Mohammad& Maier, Stephan E.& Gu, Irene Yu-Hua& Mehnert, Andrew& Kahl, Fredrik. 2015. Optimal Experiment Design for Monoexponential Model Fitting: Application to Apparent Diffusion Coefficient Imaging. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054330
Modern Language Association (MLA)
Alipoor, Mohammad…[et al.]. Optimal Experiment Design for Monoexponential Model Fitting: Application to Apparent Diffusion Coefficient Imaging. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054330
American Medical Association (AMA)
Alipoor, Mohammad& Maier, Stephan E.& Gu, Irene Yu-Hua& Mehnert, Andrew& Kahl, Fredrik. Optimal Experiment Design for Monoexponential Model Fitting: Application to Apparent Diffusion Coefficient Imaging. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054330