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Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites
Joint Authors
Muñoz, Christian
San Francisco, Juan
Gutiérrez, Bessy
González, Jorge
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In eukaryotic cells, proteasomes perform crucial roles in many cellular pathways by degrading proteins to enforce quality control and regulate many cellular processes such as cell cycle progression, signal transduction, cell death, immune responses, metabolism, protein-quality control, and development.
The catalytic heart of these complexes, the 20S proteasome, is highly conserved in bacteria, yeast, and humans.
However, until a few years ago, the role of proteasomes in parasite biology was completely unknown.
Here, we summarize findings about the role of proteasomes in protozoan parasites biology and virulence.
Several reports have confirmed the role of proteasomes in parasite biological processes such as cell differentiation, cell cycle, proliferation, and encystation.
Proliferation and cell differentiation are key steps in host colonization.
Considering the importance of proteasomes in both processes in many different parasites such as Trypanosoma, Leishmania, Toxoplasma, and Entamoeba, parasite proteasomes might serve as virulence factors.
Several pieces of evidence strongly suggest that the ubiquitin-proteasome pathway is also a viable parasitic therapeutic target.
Research in recent years has shown that the proteasome is a valid drug target for sleeping sickness and malaria.
Then, proteasomes are a key organelle in parasite biology and virulence and appear to be an attractive new chemotherapeutic target.
American Psychological Association (APA)
Muñoz, Christian& San Francisco, Juan& Gutiérrez, Bessy& González, Jorge. 2015. Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054345
Modern Language Association (MLA)
Muñoz, Christian…[et al.]. Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1054345
American Medical Association (AMA)
Muñoz, Christian& San Francisco, Juan& Gutiérrez, Bessy& González, Jorge. Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054345