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Systemic and Ocular Hemodynamic Risk Factors in Glaucoma
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Primary open angle glaucoma (POAG) is a multifactorial disease characterized by progressive retinal ganglion cell death and visual field loss.
It is known that alterations in intraocular pressure (IOP), blood pressure (BP), and ocular perfusion pressure (OPP) can play a significant role in the pathogenesis of the disease.
Impaired autoregulatory capacity of ocular blood vessels may render tissues vulnerable to OPP changes and potentially harmful tissue ischemia-reperfusion damage.
Vascular risk factors should be considered more important in a subgroup of patients with POAG, and especially in patients with normal tension glaucoma (NTG) with evidence of unphysiological BP response.
For example, reduction of BP during the nighttime has an influence on OPP, and increased circadian OPP fluctuation, which might stand for unstable ocular blood flow, has been found to be the consistent risk factor for NTG development and progression.
Central visual field may be affected more severely than peripheral visual field in NTG patients with higher 24-hour fluctuation of OPP.
This review will discuss the current understanding of allegedly major systemic and ocular hemodynamic risk factors for glaucoma including systemic hypertension, arterial stiffness, antihypertensive medication, exaggerated nocturnal hypotension, OPP, and autonomic dysregulation.
American Psychological Association (APA)
Choi, Jaewan& Kook, Michael S.. 2015. Systemic and Ocular Hemodynamic Risk Factors in Glaucoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054347
Modern Language Association (MLA)
Choi, Jaewan& Kook, Michael S.. Systemic and Ocular Hemodynamic Risk Factors in Glaucoma. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054347
American Medical Association (AMA)
Choi, Jaewan& Kook, Michael S.. Systemic and Ocular Hemodynamic Risk Factors in Glaucoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054347