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Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System
Joint Authors
De Nicola, Luca
Caccamo, Daniela
Buemi, Michele
Santoro, Domenico
Teta, Daniel
Lucisano, Silvia
Sebekova, Katerina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
For many years deficiency of vitamin D was merely identified and assimilated to the presence of bone rickets.
It is now clear that suboptimal vitamin D status may be correlated with several disorders and that the expression of 1-α-hydroxylase in tissues other than the kidney is widespread and of clinical relevance.
Recently, evidence has been collected to suggest that, beyond the traditional involvement in mineral metabolism, vitamin D may interact with other kidney hormones such as renin and erythropoietin.
This interaction would be responsible for some of the systemic and renal effects evoked for the therapy with vitamin D.
The administration of analogues of vitamin D has been associated with an improvement of anaemia and reduction in ESA requirements.
Moreover, vitamin D deficiency could contribute to an inappropriately activated or unsuppressed RAS, as a mechanism for progression of CKD and/or cardiovascular disease.
Experimental data on the anti-RAS and anti-inflammatory effects treatment with active vitamin D analogues suggest a therapeutic option particularly in proteinuric CKD patients.
This option should be considered for those subjects that are intolerant to anti-RAS agents or, as add-on therapy, in those already treated with anti-RAS but not reaching the safe threshold level of proteinuria.
American Psychological Association (APA)
Santoro, Domenico& Caccamo, Daniela& Lucisano, Silvia& Buemi, Michele& Sebekova, Katerina& Teta, Daniel…[et al.]. 2015. Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054357
Modern Language Association (MLA)
Santoro, Domenico…[et al.]. Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054357
American Medical Association (AMA)
Santoro, Domenico& Caccamo, Daniela& Lucisano, Silvia& Buemi, Michele& Sebekova, Katerina& Teta, Daniel…[et al.]. Interplay of Vitamin D, Erythropoiesis, and the Renin-Angiotensin System. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054357