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Splicing Regulators and Their Roles in Cancer Biology and Therapy
Joint Authors
da Silva, Maria Roméria
Moreira, Gabriela Alves
Gonçalves da Silva, Ronni Anderson
de Almeida Alves Barbosa, Éverton
Pais Siqueira, Raoni
Teixera, Róbson Ricardo
Fietto, Juliana Lopes Rangel
Bressan, Gustavo Costa
Almeida, Márcia Rogéria
Silva Júnior, Abelardo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Alternative splicing allows cells to expand the encoding potential of their genomes.
In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context.
Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology.
In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer.
The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail.
Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed.
American Psychological Association (APA)
da Silva, Maria Roméria& Moreira, Gabriela Alves& Gonçalves da Silva, Ronni Anderson& de Almeida Alves Barbosa, Éverton& Pais Siqueira, Raoni& Teixera, Róbson Ricardo…[et al.]. 2015. Splicing Regulators and Their Roles in Cancer Biology and Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054380
Modern Language Association (MLA)
da Silva, Maria Roméria…[et al.]. Splicing Regulators and Their Roles in Cancer Biology and Therapy. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1054380
American Medical Association (AMA)
da Silva, Maria Roméria& Moreira, Gabriela Alves& Gonçalves da Silva, Ronni Anderson& de Almeida Alves Barbosa, Éverton& Pais Siqueira, Raoni& Teixera, Róbson Ricardo…[et al.]. Splicing Regulators and Their Roles in Cancer Biology and Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1054380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054380