Comparison of Malated Ringer’s with Two Other Balanced Crystalloid Solutions in Resuscitation of Both Severe and Moderate Hemorrhagic Shock in Rats
Joint Authors
Hussmann, B.
Lendemans, S.
Keitel, Judith
de Groot, Herbert
Rohrig, Ricarda
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In preclinical treatment of polytraumatized patients crystalloids are preferentially used.
To avoid metabolic acidosis, metabolizable anions like lactate or acetate are used to replace chloride in these solutions.
We here studied the effects of malated Ringer’s in resuscitation of both shock severities in comparison to lactated and acetated Ringer’s.
Male Wistar rats underwent severe (mean arterial blood pressure (MAP) of 25–30 mmHg) or moderate (MAP 40–45 mmHg) hemorrhagic shock.
Adjacent to the shock period animals were resuscitated with acetated (AR), lactated (LR), or malated Ringer’s (MR) and observed for 150 min.
MR improved survival compared with LR and AR in severe hemorrhagic shock whereas it was equally effective to LR and superior to AR in moderate hemorrhagic shock.
In all other parameters tested, MR was also effective similar to the other solutions under these conditions.
We conclude that MR is preferable to AR and LR in resuscitation of hemorrhagic shock independent of shock depth.
The positive effects of MR may stem from the absence of any adverse impact on energy metabolism under both conditions.
American Psychological Association (APA)
Keitel, Judith& Hussmann, B.& Lendemans, S.& de Groot, Herbert& Rohrig, Ricarda. 2015. Comparison of Malated Ringer’s with Two Other Balanced Crystalloid Solutions in Resuscitation of Both Severe and Moderate Hemorrhagic Shock in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054384
Modern Language Association (MLA)
Keitel, Judith…[et al.]. Comparison of Malated Ringer’s with Two Other Balanced Crystalloid Solutions in Resuscitation of Both Severe and Moderate Hemorrhagic Shock in Rats. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054384
American Medical Association (AMA)
Keitel, Judith& Hussmann, B.& Lendemans, S.& de Groot, Herbert& Rohrig, Ricarda. Comparison of Malated Ringer’s with Two Other Balanced Crystalloid Solutions in Resuscitation of Both Severe and Moderate Hemorrhagic Shock in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054384