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Bone Marrow Pathology Predicts Mortality in Chronic Hemodialysis Patients
Joint Authors
Weng, Cheng-Hao
Yen, Tzung-Hai
Hu, Ching-Chih
Lu, Kuan-Ying
Huang, Wen-Hung
Wang, I-Kwan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
A bone marrow biopsy is a useful procedure for the diagnosis and staging of various hematologic and systemic diseases.
The objective of this study was to investigate whether the findings of bone marrow studies can predict mortality in chronic hemodialysis patients.
Methods.
Seventy-eight end-stage renal disease patients on maintenance hemodialysis underwent bone marrow biopsies between 2000 and 2011, with the most common indication being unexplained anemia followed by unexplained leukocytosis and leukopenia.
Results.
The survivors had a higher incidence of abnormal megakaryocyte distribution P = 0.001 , band and segmented cells P = 0.021 , and lymphoid cells P = 0.029 than the nonsurvivors.
The overall mortality rate was 38.5% (30/78), and the most common cause of mortality was sepsis (83.3%) followed by respiratory failure (10%).
In multivariate Cox regression analysis, both decreased (OR 3.714, 95% CI 1.671–8.253, P = 0.001 ) and absent (OR 9.751, 95% CI 2.030–45.115, P = 0.004 ) megakaryocyte distribution (normal megakaryocyte distribution as the reference group), as well as myeloid/erythroid ratio (OR 1.054, CI 1.012–1.098, P = 0.011 ), were predictive of mortality.
Conclusion.
The results of a bone marrow biopsy can be used to assess the pathology, and, in addition, myeloid/erythroid ratio and abnormal megakaryocyte distribution can predict mortality in chronic hemodialysis patients.
American Psychological Association (APA)
Weng, Cheng-Hao& Lu, Kuan-Ying& Hu, Ching-Chih& Huang, Wen-Hung& Wang, I-Kwan& Yen, Tzung-Hai. 2015. Bone Marrow Pathology Predicts Mortality in Chronic Hemodialysis Patients. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054415
Modern Language Association (MLA)
Weng, Cheng-Hao…[et al.]. Bone Marrow Pathology Predicts Mortality in Chronic Hemodialysis Patients. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054415
American Medical Association (AMA)
Weng, Cheng-Hao& Lu, Kuan-Ying& Hu, Ching-Chih& Huang, Wen-Hung& Wang, I-Kwan& Yen, Tzung-Hai. Bone Marrow Pathology Predicts Mortality in Chronic Hemodialysis Patients. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054415