PI3KAKTmTORp70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy
Joint Authors
Liu, Jun
Fan, Shengnuo
Zhang, Bei
Luan, Ping
Gu, Beibei
Wan, Qing
Huang, Xiaoyun
Liao, Wang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Disruption or deregulation of the autophagy system has been implicated in neurodegenerative disorders such as Alzheimer’s disease (AD).
Aβ plays an important role in this autophagic system.
In many cases, autophagy is regulated by the phosphatidylinositol 3-phosphate kinase/AKT/mammalian target of rapamycin/p70 ribosomal protein S6 kinase (PI3K/AKT/mTOR/p70S6K) signaling pathway.
However, whether this signaling pathway is involved in Aβ-induced autophagy in neuronal cells is not known.
Here, we studied whether Aβ25-35 induces autophagy in HT22 cells and C57 mice and investigated whether PI3K is involved in the autophagy induction.
We found that Aβ25-35 inhibited HT22 cell viability in a dose- and time-dependent manner.
Aβ25-35 induced autophagosome formation, the conversion of microtubule-associated protein light chain 3 (LC3), and the suppression of the mTOR pathway both in vitro and in vivo.
Furthermore, Aβ25-35 impaired the learning abilities of C57 mice.
Our study suggests that Aβ25-35 induces autophagy and the PI3K/AKT/mTOR/p70S6K pathway is involved in the process, which improves our understanding of the pathogenesis of AD and provides an additional model for AD research.
American Psychological Association (APA)
Fan, Shengnuo& Zhang, Bei& Luan, Ping& Gu, Beibei& Wan, Qing& Huang, Xiaoyun…[et al.]. 2015. PI3KAKTmTORp70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054419
Modern Language Association (MLA)
Fan, Shengnuo…[et al.]. PI3KAKTmTORp70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054419
American Medical Association (AMA)
Fan, Shengnuo& Zhang, Bei& Luan, Ping& Gu, Beibei& Wan, Qing& Huang, Xiaoyun…[et al.]. PI3KAKTmTORp70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054419