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Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression
Joint Authors
Izzo, Francesco
Bimonte, Sabrina
Barbieri, Antonio
Palma, Giuseppe
Arra, Claudio
Luciano, Antonio
Rea, Domenica
Cuomo, Arturo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer.
Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth.
Unfortunately, the results obtained by these studies are still contradictory.
In order to better dissect the role of morphine in cancer cell growth and angiogenesis we performed in vitro studies on ER-negative human breast carcinoma cells, MDA.MB231 and in vivo studies on heterotopic mouse model of human triple negative breast cancer, TNBC.
We demonstrated that morphine in vitro enhanced the proliferation and inhibited the apoptosis of MDA.MB231 cells.
In vivo studies performed on xenograft mouse model of TNBC revealed that tumours of mice treated with morphine were larger than those observed in other groups.
Moreover, morphine was able to enhance the neoangiogenesis.
Our data showed that morphine at clinical relevant doses promotes angiogenesis and increases breast cancer progression.
American Psychological Association (APA)
Bimonte, Sabrina& Barbieri, Antonio& Rea, Domenica& Palma, Giuseppe& Luciano, Antonio& Cuomo, Arturo…[et al.]. 2015. Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054422
Modern Language Association (MLA)
Bimonte, Sabrina…[et al.]. Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054422
American Medical Association (AMA)
Bimonte, Sabrina& Barbieri, Antonio& Rea, Domenica& Palma, Giuseppe& Luciano, Antonio& Cuomo, Arturo…[et al.]. Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054422