Binding of Citreoviridin to Human Serum Albumin: Multispectroscopic and Molecular Docking
Joint Authors
Yuqin, Li
Jia, Baoxiu
Hou, Haifeng
Qu, Xiaolan
Kong, Yueyue
Jiang, Baofa
Yao, Xiaojun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Citreoviridin (CIT), a mycotoxin produced by Penicillium citreonigrum, is a common contaminant of wide range of agriproducts and detrimental to human and animal health.
In this study, the interaction of CIT with human serum albumin (HSA) is researched by steady-state fluorescence, ultraviolet-visible (UV-Vis) absorption, circular dichroism (CD) methods, and molecular modeling.
The association constants, binding site numbers, and corresponding thermodynamic parameters are used to investigate the quenching mechanism.
The alternations of HSA secondary structure in the presence of CIT are demonstrated with UV-Vis, synchronous fluorescence, and CD spectra.
The molecular modeling results reveal that CIT can bind with hydrophobic pocket of HSA with hydrophobic and hydrogen bond force.
Moreover, an apparent distance of 3.25 nm between Trp214 and CIT is obtained via fluorescence resonance energy transfer method.
American Psychological Association (APA)
Hou, Haifeng& Qu, Xiaolan& Yuqin, Li& Kong, Yueyue& Jia, Baoxiu& Yao, Xiaojun…[et al.]. 2015. Binding of Citreoviridin to Human Serum Albumin: Multispectroscopic and Molecular Docking. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054424
Modern Language Association (MLA)
Hou, Haifeng…[et al.]. Binding of Citreoviridin to Human Serum Albumin: Multispectroscopic and Molecular Docking. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054424
American Medical Association (AMA)
Hou, Haifeng& Qu, Xiaolan& Yuqin, Li& Kong, Yueyue& Jia, Baoxiu& Yao, Xiaojun…[et al.]. Binding of Citreoviridin to Human Serum Albumin: Multispectroscopic and Molecular Docking. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054424