HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases
Joint Authors
Carrilho, Flair J.
Evangelista, Andreia Silva
Nakhle, Maria Cristina
de Araújo, Thiago Ferreira
Abrantes-Lemos, Clarice Pires
Deguti, Marta Mitiko
Cançado, Eduardo Luiz Rachid
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Iron abnormalities in chronic liver disease may be the result of genetic diseases or secondary factors.
The present study aimed to identify subjects with HFE-HH in order to describe the frequency of clinical manifestations, identify risk factors for iron elevation, and compare the iron profile of HFE-HH to other genotypes in liver disease patients.
A total of 108 individuals with hepatic disease, transferrin saturation (TS) > 45%, and serum ferritin (SF) > 350 ng/mL were tested for HFE mutations.
Two groups were characterized: C282Y/C282Y or C282Y/H63D genotypes (n=16) were the HFE hereditary hemochromatosis (HFE-HH) group; and C282Y and H63D single heterozygotes, the H63D/H63D genotype, and wild-type were considered group 2 (n=92).
Nonalcoholic liver disease, alcoholism, and chronic hepatitis C were detected more frequently in group 2, whereas arthropathy, hepatocarcinoma, diabetes, and osteoporosis rates were significantly higher in the HFE-HH group.
TS > 82%, SF > 2685 ng/mL, and serum iron > 178 μg/dL were the cutoffs for diagnosis of HFE-HH in patients with liver disease.
Thus, in non-Caucasian populations with chronic liver disease, HFE-HH diagnosis is more predictable in those with iron levels higher than those proposed in current guidelines for the general population.
American Psychological Association (APA)
Evangelista, Andreia Silva& Nakhle, Maria Cristina& de Araújo, Thiago Ferreira& Abrantes-Lemos, Clarice Pires& Deguti, Marta Mitiko& Carrilho, Flair J.…[et al.]. 2015. HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054433
Modern Language Association (MLA)
Evangelista, Andreia Silva…[et al.]. HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054433
American Medical Association (AMA)
Evangelista, Andreia Silva& Nakhle, Maria Cristina& de Araújo, Thiago Ferreira& Abrantes-Lemos, Clarice Pires& Deguti, Marta Mitiko& Carrilho, Flair J.…[et al.]. HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054433