ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies
Joint Authors
Mesuraca, Maria
Chiarella, Emanuela
Scicchitano, Stefania
Morrone, Giovanni
Bond, Heather M.
Codispoti, Bruna
Giordano, Marco
Nappo, Giovanna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The development of the B-lymphoid cell lineage is tightly controlled by the concerted action of a network of transcriptional and epigenetic regulators.
EBF1, a central component of this network, is essential for B-lymphoid specification and commitment as well as for the maintenance of the B-cell identity.
Genetic alterations causing loss of function of these B-lymphopoiesis regulators have been implicated in the pathogenesis of B-lymphoid malignancies, with particular regard to B-cell acute lymphoblastic leukaemias (B-ALLs), where their presence is frequently detected.
The activity of the B-cell regulatory network may also be disrupted by the aberrant expression of inhibitory molecules.
In particular, two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 have been characterised as potent inhibitors of EBF1 and are emerging as potentially relevant contributors to the development of B-cell leukaemias.
Here we will briefly review the current knowledge of these factors and discuss the importance of their functional cross talk with EBF1 in the development of B-cell malignancies.
American Psychological Association (APA)
Mesuraca, Maria& Chiarella, Emanuela& Scicchitano, Stefania& Codispoti, Bruna& Giordano, Marco& Nappo, Giovanna…[et al.]. 2015. ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054449
Modern Language Association (MLA)
Mesuraca, Maria…[et al.]. ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054449
American Medical Association (AMA)
Mesuraca, Maria& Chiarella, Emanuela& Scicchitano, Stefania& Codispoti, Bruna& Giordano, Marco& Nappo, Giovanna…[et al.]. ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054449