The Preventive Effect of Oxytocin to Cisplatin-Induced Neurotoxicity: An Experimental Rat Model
Joint Authors
Taskiran, Dilek
Erbas, Oytun
Terek, Mustafa Cosan
Ozsaran, Aydin
Akman, Tülay
Akman, Levent
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Peripheral neurotoxicity is a frequent dose-limiting side effect of the chemotherapeutic agent cisplatin.
This study was conducted to investigate the preventive effect of oxytocin (OT) on cisplatin-induced neurotoxicity in rats.
Forty-four adult female rats were included in the study.
Thirty-six rats were administered intraperitoneally (i.p.) single dose cisplatin 10 mg/kg and divided in to 3 groups.
The first group (n=12) received saline i.p., whereas the second group (n=12) and the third group (n=12) were injected with 80 µg/kg and 160 µg/kg OT, respectively, for 10 days.
The remaining 8 rats served as the control group.
Electromyography (EMG) studies were recorded and blood samples were collected for the measurement of plasma lipid peroxidation (malondialdehyde; MDA), tumor necrosis factor (TNF)-α, and glutathione (GSH) levels.
EMG findings revealed that compound muscle action potential amplitude was significantly decreased and distal latency was prolonged in the nontreated cisplatin-injected rats compared with the control group (P<0.005).
Also, nontreated cisplatin-injected rats showed significantly higher TNF-α and MDA levels and lower GSH level than control group.
The administration of OT significantly ameliorated the EMG alterations, suppressed oxidative stress and inflammatory parameters, and increased antioxidative capacity.
We suggest that oxytocin may have beneficial effects against cisplatin-induced neurotoxicity.
American Psychological Association (APA)
Akman, Tülay& Akman, Levent& Erbas, Oytun& Terek, Mustafa Cosan& Taskiran, Dilek& Ozsaran, Aydin. 2015. The Preventive Effect of Oxytocin to Cisplatin-Induced Neurotoxicity: An Experimental Rat Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054451
Modern Language Association (MLA)
Akman, Tülay…[et al.]. The Preventive Effect of Oxytocin to Cisplatin-Induced Neurotoxicity: An Experimental Rat Model. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1054451
American Medical Association (AMA)
Akman, Tülay& Akman, Levent& Erbas, Oytun& Terek, Mustafa Cosan& Taskiran, Dilek& Ozsaran, Aydin. The Preventive Effect of Oxytocin to Cisplatin-Induced Neurotoxicity: An Experimental Rat Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054451