A Potential Epigenetic Marker Mediating Serum Folate and Vitamin B 12 Levels Contributes to the Risk of Ischemic Stroke
Joint Authors
Keat Wei, Loo
Sutherland, Heidi
Au, Anthony
Camilleri, Emily
Haupt, Larisa M.
Gan, Siew Hua
Griffiths, Lyn R.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Stroke is a multifactorial disease that may be associated with aberrant DNA methylation profiles.
We investigated epigenetic dysregulation for the methylenetetrahydrofolate reductase (MTHFR) gene among ischemic stroke patients.
Cases and controls were recruited after obtaining signed written informed consents following a screening process against the inclusion/exclusion criteria.
Serum vitamin profiles (folate, vitamin B12, and homocysteine) were determined using immunoassays.
Methylation profiles for CpGs A and B in the MTHFR gene were determined using a bisulfite-pyrosequencing method.
Methylation of MTHFR significantly increased the susceptibility risk for ischemic stroke.
In particular, CpG A outperformed CpG B in mediating serum folate and vitamin B12 levels to increase ischemic stroke susceptibility risks by 4.73-fold.
However, both CpGs A and B were not associated with serum homocysteine levels or ischemic stroke severity.
CpG A is a potential epigenetic marker in mediating serum folate and vitamin B12 to contribute to ischemic stroke.
American Psychological Association (APA)
Keat Wei, Loo& Sutherland, Heidi& Au, Anthony& Camilleri, Emily& Haupt, Larisa M.& Gan, Siew Hua…[et al.]. 2015. A Potential Epigenetic Marker Mediating Serum Folate and Vitamin B 12 Levels Contributes to the Risk of Ischemic Stroke. BioMed Research International،Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1054456
Modern Language Association (MLA)
Keat Wei, Loo…[et al.]. A Potential Epigenetic Marker Mediating Serum Folate and Vitamin B 12 Levels Contributes to the Risk of Ischemic Stroke. BioMed Research International No. 2015 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1054456
American Medical Association (AMA)
Keat Wei, Loo& Sutherland, Heidi& Au, Anthony& Camilleri, Emily& Haupt, Larisa M.& Gan, Siew Hua…[et al.]. A Potential Epigenetic Marker Mediating Serum Folate and Vitamin B 12 Levels Contributes to the Risk of Ischemic Stroke. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-4.
https://search.emarefa.net/detail/BIM-1054456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054456