Epithelial-Mesenchymal Transition in Keratocystic Odontogenic Tumor: Possible Role in Locally Aggressive Behavior

Joint Authors

Zhong, Wen-Qun
Chen, Gang
Zhang, Wei
Ren, Jian-Gang
Wu, Zhong-Xing
Zhao, Yi
Zhao, Yi-Fang
Liu, Bing

Source

BioMed Research International

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-03-23

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

The aim of this study is to clarify whether epithelial-mesenchymal transition (EMT) is involved in the pathogenesis and development of keratocystic odontogenic tumor (KCOT).

The expression levels of EMT-related proteins and genes in normal oral mucosa (OM), radicular cyst (RC), and KCOT were determined and compared by real-time quantitative PCR and immunohistochemistry.

Our data showed that the expression of epithelial markers E-cadherin and Pan-cytokeratin was significantly downregulated in KCOT with upregulation of mesenchymal markers N-cadherin compared to OM and RC.

Importantly, TGF-β, a potent EMT inducer, and Slug, a master transcription factor, were also found highly expressed in KCOT.

In addition, the results from Spearman rank correlation test and clustering analysis revealed the close relationship between Slug and MMP-9, which was further evidenced by double-labeling immunofluorescence that revealed a synchronous distribution for Slug with MMP-9 in KCOT samples.

All the data suggested EMT might be involved in the locally aggressive behavior of KCOT.

American Psychological Association (APA)

Zhong, Wen-Qun& Chen, Gang& Zhang, Wei& Ren, Jian-Gang& Wu, Zhong-Xing& Zhao, Yi…[et al.]. 2015. Epithelial-Mesenchymal Transition in Keratocystic Odontogenic Tumor: Possible Role in Locally Aggressive Behavior. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054457

Modern Language Association (MLA)

Zhong, Wen-Qun…[et al.]. Epithelial-Mesenchymal Transition in Keratocystic Odontogenic Tumor: Possible Role in Locally Aggressive Behavior. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054457

American Medical Association (AMA)

Zhong, Wen-Qun& Chen, Gang& Zhang, Wei& Ren, Jian-Gang& Wu, Zhong-Xing& Zhao, Yi…[et al.]. Epithelial-Mesenchymal Transition in Keratocystic Odontogenic Tumor: Possible Role in Locally Aggressive Behavior. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054457

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1054457