A Population-Based Model to Consider the Effect of Seasonal Variation on Serum 25(OH)D and Vitamin D Status
Joint Authors
Guessous, Idris
Gaspoz, Jean-Michel
Waeber, Gérard
Vuistiner, Philippe
Rousson, Valentin
Henry, Hugues
Lescuyer, Pierre
Boulat, Olivier
Mooser, Vincent
Vollenweider, Peter
Cornuz, Jacques
Bochud, Murielle
Paccaud, Fred
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
We elaborated a model that predicts the centiles of the 25(OH)D distribution taking into account seasonal variation.
Methods.
Data from two Swiss population-based studies were used to generate (CoLaus) and validate (Bus Santé) the model.
Serum 25(OH)D was measured by ultra high pressure LC-MS/MS and immunoassay.
Linear regression models on square-root transformed 25(OH)D values were used to predict centiles of the 25(OH)D distribution.
Distribution functions of the observations from the replication set predicted with the model were inspected to assess replication.
Results.
Overall, 4,912 and 2,537 Caucasians were included in original and replication sets, respectively.
Mean (SD) 25(OH)D, age, BMI, and % of men were 47.5 (22.1) nmol/L, 49.8 (8.5) years, 25.6 (4.1) kg/m2, and 49.3% in the original study.
The best model included gender, BMI, and sin-cos functions of measurement day.
Sex- and BMI-specific 25(OH)D centile curves as a function of measurement date were generated.
The model estimates any centile of the 25(OH)D distribution for given values of sex, BMI, and date and the quantile corresponding to a 25(OH)D measurement.
Conclusions.
We generated and validated centile curves of 25(OH)D in the general adult Caucasian population.
These curves can help rank vitamin D centile independently of when 25(OH)D is measured.
American Psychological Association (APA)
Vuistiner, Philippe& Rousson, Valentin& Henry, Hugues& Lescuyer, Pierre& Boulat, Olivier& Gaspoz, Jean-Michel…[et al.]. 2015. A Population-Based Model to Consider the Effect of Seasonal Variation on Serum 25(OH)D and Vitamin D Status. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054458
Modern Language Association (MLA)
Vuistiner, Philippe…[et al.]. A Population-Based Model to Consider the Effect of Seasonal Variation on Serum 25(OH)D and Vitamin D Status. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054458
American Medical Association (AMA)
Vuistiner, Philippe& Rousson, Valentin& Henry, Hugues& Lescuyer, Pierre& Boulat, Olivier& Gaspoz, Jean-Michel…[et al.]. A Population-Based Model to Consider the Effect of Seasonal Variation on Serum 25(OH)D and Vitamin D Status. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054458