Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults
Joint Authors
Huang, Ying
Ogutu, James O.
Gu, Jiarui
Ding, Fengshu
You, Yuhong
Huo, Yan
Zhao, Hong
Li, Wenjing
Zhang, Zhiwei
Zhang, Wenli
Chen, Xiaobei
Fu, Yingmei
Zhang, Fengmin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The objective of this study was to compare quinolone resistance and gyrA mutations in clinical isolates of Klebsiella pneumoniae and Escherichia coli from Chinese adults who used quinolone in the preceding month and children without any known history of quinolone administration.
The antimicrobial susceptibilities of 61 isolates from children and 79 isolates from adults were determined.
The mutations in the quinolone resistance-determining regions in gyrA gene were detected by PCR and DNA sequencing.
Fluoroquinolone resistance and types of gyrA mutations in isolates from children and adults were compared and statistically analyzed.
No significant differences were detected in the resistance rates of ciprofloxacin and levofloxacin between children and adults among isolates of the two species (all P>0.05).
The double mutation Ser83→Leu + Asp87→Asn in the ciprofloxacin-resistant isolates occurred in 73.7% isolates from the children and 67.9% from the adults, respectively (P=0.5444).
Children with no known history of quinolone administration were found to carry fluoroquinolone-resistant Enterobacteriaceae isolates.
The occurrence of ciprofloxacin resistance and the major types of gyrA mutations in the isolates from the children were similar to those from adults.
The results indicate that precautions should be taken on environmental issues resulting from widespread transmission of quinolone resistance.
American Psychological Association (APA)
Huang, Ying& Ogutu, James O.& Gu, Jiarui& Ding, Fengshu& You, Yuhong& Huo, Yan…[et al.]. 2015. Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054459
Modern Language Association (MLA)
Huang, Ying…[et al.]. Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1054459
American Medical Association (AMA)
Huang, Ying& Ogutu, James O.& Gu, Jiarui& Ding, Fengshu& You, Yuhong& Huo, Yan…[et al.]. Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1054459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054459