Evolutionary and Expression Analysis of miR-#-5p and miR-#-3p at the miRNAsisomiRs Levels
Joint Authors
Zhao, Yang
Guo, Li
Yu, Jiafeng
Yu, Hao
Chen, Shujie
Xu, Changqing
Chen, Feng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
We mainly discussed miR-#-5p and miR-#-3p under three aspects: (1) primary evolutionary analysis of human miRNAs; (2) evolutionary analysis of miRNAs from different arms across the typical 10 vertebrates; (3) expression pattern analysis of miRNAs at the miRNA/isomiR levels using public small RNA sequencing datasets.
We found that no bias can be detected between the numbers of 5p-miRNA and 3p-miRNA, while miRNAs from miR-#-5p and miR-#-3p show variable nucleotide compositions.
IsomiR expression profiles from the two arms are always stable, but isomiR expressions in diseased samples are prone to show larger degree of dispersion.
miR-#-5p and miR-#-3p have relative independent evolution/expression patterns and datasets of target mRNAs, which might also contribute to the phenomena of arm selection and/or arm switching.
Simultaneously, miRNA/isomiR expression profiles may be regulated via arm selection and/or arm switching, and the dynamic miRNAome and isomiRome will adapt to functional and/or evolutionary pressures.
A comprehensive analysis and further experimental study at the miRNA/isomiR levels are quite necessary for miRNA study.
American Psychological Association (APA)
Guo, Li& Yu, Jiafeng& Yu, Hao& Zhao, Yang& Chen, Shujie& Xu, Changqing…[et al.]. 2015. Evolutionary and Expression Analysis of miR-#-5p and miR-#-3p at the miRNAsisomiRs Levels. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054461
Modern Language Association (MLA)
Guo, Li…[et al.]. Evolutionary and Expression Analysis of miR-#-5p and miR-#-3p at the miRNAsisomiRs Levels. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1054461
American Medical Association (AMA)
Guo, Li& Yu, Jiafeng& Yu, Hao& Zhao, Yang& Chen, Shujie& Xu, Changqing…[et al.]. Evolutionary and Expression Analysis of miR-#-5p and miR-#-3p at the miRNAsisomiRs Levels. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054461