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Drug Induced Steatohepatitis: An Uncommon Culprit of a Common Disease
Joint Authors
Rabinowich, Liane
Shibolet, Oren
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease in developed countries.
Its frequency is increasing in the general population mostly due to the widespread occurrence of obesity and the metabolic syndrome.
Although drugs and dietary supplements are viewed as a major cause of acute liver injury, drug induced steatosis and steatohepatitis are considered a rare form of drug induced liver injury (DILI).
The complex mechanism leading to hepatic steatosis caused by commonly used drugs such as amiodarone, methotrexate, tamoxifen, valproic acid, glucocorticoids, and others is not fully understood.
It relates not only to induction of the metabolic syndrome by some drugs but also to their impact on important molecular pathways including increased hepatocytes lipogenesis, decreased secretion of fatty acids, and interruption of mitochondrial β-oxidation as well as altered expression of genes responsible for drug metabolism.
Better familiarity with this type of liver injury is important for early recognition of drug hepatotoxicity and crucial for preventing severe forms of liver injury and cirrhosis.
Moreover, understanding the mechanisms leading to drug induced hepatic steatosis may provide much needed clues to the mechanism and potential prevention of the more common form of metabolic steatohepatitis.
American Psychological Association (APA)
Rabinowich, Liane& Shibolet, Oren. 2015. Drug Induced Steatohepatitis: An Uncommon Culprit of a Common Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054465
Modern Language Association (MLA)
Rabinowich, Liane& Shibolet, Oren. Drug Induced Steatohepatitis: An Uncommon Culprit of a Common Disease. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1054465
American Medical Association (AMA)
Rabinowich, Liane& Shibolet, Oren. Drug Induced Steatohepatitis: An Uncommon Culprit of a Common Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054465