Mass Spectrometry in Pharmacokinetic Studies of a Synthetic Compound for Spinal Cord Injury Treatment
Joint Authors
Sánchez-Sierra, María
García-Álvarez, Isabel
Fernández-Mayoralas, Alfonso
Moreno-Lillo, Sandra
Barroso García, Gemma
Moral Dardé, Verónica
Doncel-Pérez, Ernesto
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The studies of drugs that could constitute a palliative to spinal cord injury (SCI) are a continuous and increasing demand in biomedicine field from developed societies.
Recently we described the chemical synthesis and antiglioma activity of synthetic glycosides.
A synthetic sulfated glycolipid (here IG20) has shown chemical stability, solubility in polar solvents, and high inhibitory capacity over glioma growth.
We have used mass spectrometry (MS) to monitor IG20 m/z=550.3 in cells and tissues of the central nervous system (CNS) that are involved in SCI recovery.
IG20 was detected by MS in serum and homogenates from CNS tissue of rats, though in the latter a previous deproteinization step was required.
The pharmacokinetic parameters of serum clearance at 24 h and half-life at 4 h were determined for synthetic glycoside in the adult rat using MS.
A local administration of the drug near of spinal lesion site is proposed.
American Psychological Association (APA)
Sánchez-Sierra, María& García-Álvarez, Isabel& Fernández-Mayoralas, Alfonso& Moreno-Lillo, Sandra& Barroso García, Gemma& Moral Dardé, Verónica…[et al.]. 2015. Mass Spectrometry in Pharmacokinetic Studies of a Synthetic Compound for Spinal Cord Injury Treatment. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054468
Modern Language Association (MLA)
Sánchez-Sierra, María…[et al.]. Mass Spectrometry in Pharmacokinetic Studies of a Synthetic Compound for Spinal Cord Injury Treatment. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054468
American Medical Association (AMA)
Sánchez-Sierra, María& García-Álvarez, Isabel& Fernández-Mayoralas, Alfonso& Moreno-Lillo, Sandra& Barroso García, Gemma& Moral Dardé, Verónica…[et al.]. Mass Spectrometry in Pharmacokinetic Studies of a Synthetic Compound for Spinal Cord Injury Treatment. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054468