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Adventitial Alterations Are the Main Features in Pulmonary Artery Remodeling due to Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats
Joint Authors
Arribas, Silvia M.
Flores, Karen
Pulido, Ruth
Ordenes, Stefany
Brito, Julio
González, María Carmen
López, M. Rosario
León-Velarde, Fabiola
Siques, Patricia
Naveas, Nelson
López de Pablo, Ángel Luis
Arriaza, Karem
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research.
Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features.
Rats were subjected to chronic hypoxia (CH, n = 9 ) and long-term intermittent hypoxia (CIH2x2; 2 days of hypoxia/2 days of normoxia, n = 10 ) in a chamber (428 Torr, 4,600 m of altitude) for 46 days and compared to rats under normoxia (NX, n = 10 ).
Body weight, hematocrit, and right ventricle ratio were measured.
Pulmonary artery remodeling was assessed using confocal microscopy of tissues stained with a nuclear dye (DAPI) and CD11b antibody.
Both hypoxic conditions exhibited increased hematocrit and hypertrophy of the right ventricle, tunica adventitia, and tunica media, with no changes in lumen size.
The medial hypertrophy area (larger in CH) depicted a significant increase in smooth muscle cell number.
Additionally, CIH2x2 increased the adventitial hypertrophy area, with an increased cellularity and a larger prevalence of clustered inflammatory cells.
In conclusion, CIH2x2 elicits milder effects on pulmonary artery medial layer muscularization and subsequent right ventricular hypertrophy than CH.
However, CIH2x2 induces greater and characteristic alterations of the adventitial layer.
American Psychological Association (APA)
Brito, Julio& Siques, Patricia& Arribas, Silvia M.& López de Pablo, Ángel Luis& González, María Carmen& Naveas, Nelson…[et al.]. 2015. Adventitial Alterations Are the Main Features in Pulmonary Artery Remodeling due to Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054473
Modern Language Association (MLA)
Brito, Julio…[et al.]. Adventitial Alterations Are the Main Features in Pulmonary Artery Remodeling due to Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054473
American Medical Association (AMA)
Brito, Julio& Siques, Patricia& Arribas, Silvia M.& López de Pablo, Ángel Luis& González, María Carmen& Naveas, Nelson…[et al.]. Adventitial Alterations Are the Main Features in Pulmonary Artery Remodeling due to Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054473