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Characterizing Spatial Dynamics of Bifurcation to Alternans in Isolated Whole Rabbit Hearts Based on Alternate Pacing
Joint Authors
Zhao, Xiaopeng
Kulkarni, Kanchan
Visweswaran, Ramjay
Tolkacheva, Elena G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sudden cardiac death instigated by ventricular fibrillation (VF) is the largest cause of natural death in the USA.
Alternans, a beat-to-beat alternation in the action potential duration, has been implicated as being proarrhythmic.
The onset of alternans is mediated via a bifurcation, which may occur through either a smooth or a border-collision mechanism.
The objective of this study was to characterize the mechanism of bifurcation to alternans based on experiments in isolated whole rabbit hearts.
High resolution optical mapping was performed and the electrical activity was recorded from the left ventricle (LV) epicardial surface of the heart.
Each heart was paced using an “alternate pacing protocol,” where the basic cycle length (BCL) was alternatively perturbed by ±δ.
Local onset of alternans in the heart, BCLstart, was measured in the absence of perturbations (δ=0) and was defined as the BCL at which 10% of LV exhibited alternans.
The influences of perturbation size were investigated at two BCLs: one prior to BCLstart (BCLprior=BCLstart+20 ms) and one preceding BCLprior (BCLfar=BCLstart+40 ms).
Our results demonstrate significant spatial correlation of the region exhibiting alternans with smooth bifurcation characteristics, indicating that transition to alternans in isolated rabbit hearts occurs predominantly through smooth bifurcation.
American Psychological Association (APA)
Kulkarni, Kanchan& Visweswaran, Ramjay& Zhao, Xiaopeng& Tolkacheva, Elena G.. 2015. Characterizing Spatial Dynamics of Bifurcation to Alternans in Isolated Whole Rabbit Hearts Based on Alternate Pacing. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054479
Modern Language Association (MLA)
Kulkarni, Kanchan…[et al.]. Characterizing Spatial Dynamics of Bifurcation to Alternans in Isolated Whole Rabbit Hearts Based on Alternate Pacing. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054479
American Medical Association (AMA)
Kulkarni, Kanchan& Visweswaran, Ramjay& Zhao, Xiaopeng& Tolkacheva, Elena G.. Characterizing Spatial Dynamics of Bifurcation to Alternans in Isolated Whole Rabbit Hearts Based on Alternate Pacing. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054479