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Immunohistochemical Expression of Ornithine Decarboxylase, Diamine Oxidase, Putrescine, and Spermine in Normal Canine Enterocolic Mucosa, in Chronic Colitis, and in Colorectal Cancer
Joint Authors
Rossi, Giacomo
Cerquetella, Matteo
Pengo, Graziano
Mari, Subeide
Balint, Emilia
Manolescu, Nicolae
Bassotti, Gabrio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We compared the immunohistochemical expression of putrescine (PUT), spermine (SPM), ornithine decarboxylase (ODC), and diamine oxidase (DAO) in bioptic samples of canine colonic mucosa with chronic inflammation (i.e., granulomatous colitis and lymphoplasmacytic colitis) or neoplasia.
Single and total polyamines levels were significantly higher in neoplastic tissue than in normal samples.
Samples with different degrees of inflammation showed a general decrease expression of ODC if compared to controls; SPM was practically not expressed in control samples and very low in samples with chronic-granulomatous inflammation.
In carcinomatous samples, the ODC activity was higher with respect to controls and samples with inflammation.
This is the first description of polyamines expression in dog colonic mucosa in normal and in different pathological conditions, suggesting that the balance between polyamine degradation and biosynthesis is evidently disengaged during neoplasia.
American Psychological Association (APA)
Rossi, Giacomo& Cerquetella, Matteo& Pengo, Graziano& Mari, Subeide& Balint, Emilia& Bassotti, Gabrio…[et al.]. 2015. Immunohistochemical Expression of Ornithine Decarboxylase, Diamine Oxidase, Putrescine, and Spermine in Normal Canine Enterocolic Mucosa, in Chronic Colitis, and in Colorectal Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054491
Modern Language Association (MLA)
Rossi, Giacomo…[et al.]. Immunohistochemical Expression of Ornithine Decarboxylase, Diamine Oxidase, Putrescine, and Spermine in Normal Canine Enterocolic Mucosa, in Chronic Colitis, and in Colorectal Cancer. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054491
American Medical Association (AMA)
Rossi, Giacomo& Cerquetella, Matteo& Pengo, Graziano& Mari, Subeide& Balint, Emilia& Bassotti, Gabrio…[et al.]. Immunohistochemical Expression of Ornithine Decarboxylase, Diamine Oxidase, Putrescine, and Spermine in Normal Canine Enterocolic Mucosa, in Chronic Colitis, and in Colorectal Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054491