Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer’s Disease
Joint Authors
Thomas, J.
Thomas, C. J.
Radcliffe, J.
Itsiopoulos, C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the leading cause of dementia and the most common neurodegenerative disease in the elderly.
Furthermore, AD has provided the most positive indication to support the fact that inflammation contributes to neurodegenerative disease.
The exact etiology of AD is unknown, but environmental and genetic factors are thought to contribute, such as advancing age, family history, presence of chronic diseases such as cardiovascular disease (CVD) and diabetes, and poor diet and lifestyle.
It is hypothesised that early prevention or management of inflammation could delay the onset or reduce the symptoms of AD.
Normal physiological changes to the brain with ageing include depletion of long chain omega-3 fatty acids and brains of AD patients have lower docosahexaenoic acid (DHA) levels.
DHA supplementation can reduce markers of inflammation.
This review specifically focusses on the evidence in humans from epidemiological, dietary intervention, and supplementation studies, which supports the role of long chain omega-3 fatty acids in the prevention or delay of cognitive decline in AD in its early stages.
Longer term trials with long chain omega-3 supplementation in early stage AD are warranted.
We also highlight the importance of overall quality and composition of the diet to protect against AD and dementia.
American Psychological Association (APA)
Thomas, J.& Thomas, C. J.& Radcliffe, J.& Itsiopoulos, C.. 2015. Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer’s Disease. BioMed Research International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054492
Modern Language Association (MLA)
Thomas, J.…[et al.]. Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer’s Disease. BioMed Research International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1054492
American Medical Association (AMA)
Thomas, J.& Thomas, C. J.& Radcliffe, J.& Itsiopoulos, C.. Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer’s Disease. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1054492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054492