Neurotensin Branched Peptide as a Tumor-Targeting Agent for Human Bladder Cancer
Joint Authors
Carini, M.
Brunetti, Jlenia
Falciani, Chiara
Lelli, Barbara
Minervini, Andrea
Ravenni, Niccolò
Depau, Lorenzo
Siena, Giampaolo
Tenori, Eleonora
Menichetti, Stefano
Pini, Alessandro
Bracci, Luisa
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Despite recent advances in multimodal therapy, bladder cancer still ranks ninth in worldwide cancer incidence.
New molecules which might improve early diagnosis and therapeutic efficiency for tumors of such high epidemiological impact therefore have very high priority.
In the present study, the tetrabranched neurotensin peptide NT4 was conjugated with functional units for cancer-cell imaging or therapy and was tested on bladder cancer cell lines and specimens from bladder cancer surgical resections, in order to evaluate its potential for targeted personalized therapy of bladder cancer.
Fluorophore-conjugated NT4 distinguished healthy and cancer tissues with good statistical significance P<0.05.
NT4 conjugated to methotrexate or gemcitabine was cytotoxic for human bladder cancer cell lines at micromolar concentrations.
Their selectivity for bladder cancer tissue and capacity to carry tracers or drugs make NT4 peptides candidate tumor targeting agents for tracing cancer cells and for personalized therapy of human bladder cancer.
American Psychological Association (APA)
Brunetti, Jlenia& Falciani, Chiara& Lelli, Barbara& Minervini, Andrea& Ravenni, Niccolò& Depau, Lorenzo…[et al.]. 2015. Neurotensin Branched Peptide as a Tumor-Targeting Agent for Human Bladder Cancer. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054497
Modern Language Association (MLA)
Brunetti, Jlenia…[et al.]. Neurotensin Branched Peptide as a Tumor-Targeting Agent for Human Bladder Cancer. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054497
American Medical Association (AMA)
Brunetti, Jlenia& Falciani, Chiara& Lelli, Barbara& Minervini, Andrea& Ravenni, Niccolò& Depau, Lorenzo…[et al.]. Neurotensin Branched Peptide as a Tumor-Targeting Agent for Human Bladder Cancer. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054497