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Serum Caveolin-1 as a Novel Biomarker in Idiopathic Pulmonary Artery Hypertension
Joint Authors
Wang, Kuo-Yang
Lee, Mey-Fann
Ho, Hung-Chin
Liu, Chia-Chi
Tsai, Wan-Jane
Lin, Wei-Wen
Liang, Kae-Woei
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pulmonary arterial hypertension (PAH) is a rare disease but with significant morbidity and high mortality.
There is no specific way to diagnose PAH.
Thus, an easy used with good sensitivity and specificity biomarker of PAH is highly desirable to aid in the screening, diagnosis, and follow-up.
Caveolin-1 (Cav1) is the structural protein of caveolae and is highly expressed in type I pneumocytes.
Lungs tissues from idiopathic PAH (IPAH) patients showed decreased expression of Cav1 in vascular endothelial cells.
Therefore, we developed a direct sandwich immunoassay for the determination of Cav1 in IAPH patient’s serum.
The result disclosed serum Cav1 level was significantly lower in IPAH than control groups.
Using serum Cav1, 17.17 pg/mL as a cutoff value, the sensitivity was 0.59 and the specificity was 1.0.
There were two major findings in our results.
First, serum Cav1 might be a novel biomarker in the diagnosis of IPAH with fare sensitivity and good specificity.
Second, Cav1 might be used to make differential diagnosis between COPD-PH and IPAH group.
American Psychological Association (APA)
Wang, Kuo-Yang& Lee, Mey-Fann& Ho, Hung-Chin& Liang, Kae-Woei& Liu, Chia-Chi& Tsai, Wan-Jane…[et al.]. 2015. Serum Caveolin-1 as a Novel Biomarker in Idiopathic Pulmonary Artery Hypertension. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054500
Modern Language Association (MLA)
Wang, Kuo-Yang…[et al.]. Serum Caveolin-1 as a Novel Biomarker in Idiopathic Pulmonary Artery Hypertension. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054500
American Medical Association (AMA)
Wang, Kuo-Yang& Lee, Mey-Fann& Ho, Hung-Chin& Liang, Kae-Woei& Liu, Chia-Chi& Tsai, Wan-Jane…[et al.]. Serum Caveolin-1 as a Novel Biomarker in Idiopathic Pulmonary Artery Hypertension. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054500