Examination of Local Functional Homogeneity in Autism
Joint Authors
Jiang, Lili
Yang, Ning
Yang, Zhi
Zuo, Xi-Nian
Hou, Xiao-Hui
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Increasing neuroimaging evidence suggests that autism patients exhibit abnormal brain structure and function.
We used the Autism Brain Imaging Data Exchange (ABIDE) sample to analyze locally focal (~8 mm) functional connectivity of 223 autism patients and 285 normal controls from 15 international sites using a recently developed surface-based approach.
We observed enhanced local connectivity in the middle frontal cortex, left precuneus, and right superior temporal sulcus, and reduced local connectivity in the right insular cortex.
The local connectivity in the right middle frontal gyrus was positively correlated with the total score of the autism diagnostic observation schedule whereas the local connectivity within the right superior temporal sulcus was positively correlated with total subscores of both the communication and the stereotyped behaviors and restricted interests of the schedule.
Finally, significant interactions between age and clinical diagnosis were detected in the left precuneus.
These findings replicated previous observations that used a volume-based approach and suggested possible neuropathological impairments of local information processing in the frontal, temporal, parietal, and insular cortices.
Novel site-variability analysis demonstrated high reproducibility of our findings across the 15 international sites.
The age-disease interaction provides a potential target region for future studies to further elucidate the neurodevelopmental mechanisms of autism.
American Psychological Association (APA)
Jiang, Lili& Hou, Xiao-Hui& Yang, Ning& Yang, Zhi& Zuo, Xi-Nian. 2015. Examination of Local Functional Homogeneity in Autism. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054503
Modern Language Association (MLA)
Jiang, Lili…[et al.]. Examination of Local Functional Homogeneity in Autism. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1054503
American Medical Association (AMA)
Jiang, Lili& Hou, Xiao-Hui& Yang, Ning& Yang, Zhi& Zuo, Xi-Nian. Examination of Local Functional Homogeneity in Autism. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1054503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054503