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Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balbc Mice
Joint Authors
Sánchez-Ramírez, Blanca
Gutiérrez-Torres, Daniela Sarahí
González-Horta, Carmen
Del Razo, Luz María
Infante-Ramírez, Rocío
Ramos-Martínez, Ernesto
Levario-Carrillo, Margarita
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inorganic arsenic (iAs) exposure induces a decrease in glucose type 4 transporter (GLUT4) expression on the adipocyte membrane, which may be related to premature births and low birth weight infants in women exposed to iAs at reproductive age.
The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology.
Female Balb/c mice ( n = 15 ) were exposed to 0, 12, and 20 ppm of NaAsO2 in drinking water from 8th to 18th day of gestation.
Morphological changes and GLUT1, GLUT3, and GLUT4 expression were evaluated in placentas by immunohistochemical and image analysis and correlated with iAs and arsenical species concentration, which were quantified by atomic absorption spectroscopy.
NaAsO2 exposure induced a significant decrease in fetal and placental weight ( P < 0.01 ) and increases in infarctions and vascular congestion.
Whereas GLUT1 expression was unchanged in placentas from exposed group, GLUT3 expression was found increased.
In contrast, GLUT4 expression was significantly lower ( P < 0.05 ) in placentas from females exposed to 12 ppm.
The decrease in placental GLUT4 expression might affect the provision of adequate fetal nutrition and explain the low fetal weight observed in the exposed groups.
American Psychological Association (APA)
Gutiérrez-Torres, Daniela Sarahí& González-Horta, Carmen& Del Razo, Luz María& Infante-Ramírez, Rocío& Ramos-Martínez, Ernesto& Levario-Carrillo, Margarita…[et al.]. 2015. Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balbc Mice. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054506
Modern Language Association (MLA)
Gutiérrez-Torres, Daniela Sarahí…[et al.]. Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balbc Mice. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1054506
American Medical Association (AMA)
Gutiérrez-Torres, Daniela Sarahí& González-Horta, Carmen& Del Razo, Luz María& Infante-Ramírez, Rocío& Ramos-Martínez, Ernesto& Levario-Carrillo, Margarita…[et al.]. Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balbc Mice. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1054506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054506