The Significance of Metastasectomy in Patients with Metastatic Renal Cell Carcinoma in the Era of Targeted Therapy
Joint Authors
He, Zhisong
Song, Yi
Yu, Xiaoteng
Wang, Bing
Lin, Gang
Zhang, Cuijian
Yang, Yang
Zhou, Liqun
Li, Xuesong
Fang, Dong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To investigate the efficacy of surgery in the treatment of metastatic renal cell carcinoma (mRCC) and to identify prognostic factors.
Methods.
A single center retrospective study of 96 patients with mRCC from December 2004 to August 2013.
Results.
The median follow-up time was 45 months.
Thirty-one (32.3%) of the patients received complete resection of metastatic sites, 11 (11.5%) of the patients underwent incomplete resection of metastatic sites, and 54 (56.3%) of the patients received no surgery.
In the univariate Kaplan-Meier analysis, the median overall survival times of the three groups were 52 months, 16 months, and 22 months, respectively (p<0.001).
The difference in the overall survival time was statistically significant between complete resection and no surgery groups (HR = 0.43, p=0.009), while there was no significant difference between the incomplete metastasectomy and no surgery groups (HR = 1.80, p=0.102).
According to the multivariate Cox regression analysis, complete metastasectomy (HR = 0.49, p=0.033), T stage > 3 (HR = 1.88, p=0.015), disease free interval <12 months (HR = 2.34, p=0.003), and multiorgan involvement (HR = 2.00, p=0.011) were significant prognostic factors.
Conclusion.
In the era of targeted therapy, complete metastasectomy can improve overall survival.
Complete metastasectomy, T stage > 3, disease free interval <12 months, and multiorgan involvement are independent prognostic factors.
American Psychological Association (APA)
Yu, Xiaoteng& Wang, Bing& Li, Xuesong& Lin, Gang& Zhang, Cuijian& Yang, Yang…[et al.]. 2015. The Significance of Metastasectomy in Patients with Metastatic Renal Cell Carcinoma in the Era of Targeted Therapy. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054511
Modern Language Association (MLA)
Yu, Xiaoteng…[et al.]. The Significance of Metastasectomy in Patients with Metastatic Renal Cell Carcinoma in the Era of Targeted Therapy. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054511
American Medical Association (AMA)
Yu, Xiaoteng& Wang, Bing& Li, Xuesong& Lin, Gang& Zhang, Cuijian& Yang, Yang…[et al.]. The Significance of Metastasectomy in Patients with Metastatic Renal Cell Carcinoma in the Era of Targeted Therapy. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054511