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AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4
Joint Authors
Robison de Oliveira, Jhony
Silva Teixeira, David Nascimento
Tanaka, Sarah Cristina Sato Vaz
Balarin, Marly Aparecida Spadotto
Levy, Bruce David
Favarin, Daniely Cornélio
de Paula Rogerio, Alexandre
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bronchial epithelial cells represent the first line of defense against microorganisms and allergens in the airways and play an important role in chronic inflammatory processes such as asthma.
In an experimental model, both RvD1 and AT-RvD1, lipid mediators of inflammation resolution, ameliorated some of the most important phenotypes of experimental asthma.
Here, we extend these results and demonstrate the effect of AT-RvD1 on bronchial epithelial cells (BEAS-2B) stimulated with IL-4.
AT-RvD1 (100 nM) decreased both CCL2 and CXCL-8 production, in part by decreasing STAT6 and NF-κB pathways.
Furthermore, the effects of AT-RvD1 were ALX/FRP2 receptor dependent, as the antagonist of this receptor (BOC1) reversed the inhibition of these chemokines by AT-RvD1.
In addition, AT-RvD1 decreased SOCS1 and increased SOCS3 expression, which play important roles in Th1 and Th17 modulation, respectively.
In conclusion, AT-RvD1 demonstrated significant effects on the IL-4-induced activation of bronchial epithelial cells and consequently the potential to modulate neutrophilic and eosinophilic airway inflammation in asthma.
Taken together, these findings identify AT-RvD1 as a potential proresolving therapeutic agent for allergic responses in the airways.
American Psychological Association (APA)
Robison de Oliveira, Jhony& Favarin, Daniely Cornélio& Tanaka, Sarah Cristina Sato Vaz& Balarin, Marly Aparecida Spadotto& Silva Teixeira, David Nascimento& Levy, Bruce David…[et al.]. 2015. AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054513
Modern Language Association (MLA)
Robison de Oliveira, Jhony…[et al.]. AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054513
American Medical Association (AMA)
Robison de Oliveira, Jhony& Favarin, Daniely Cornélio& Tanaka, Sarah Cristina Sato Vaz& Balarin, Marly Aparecida Spadotto& Silva Teixeira, David Nascimento& Levy, Bruce David…[et al.]. AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054513