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The Effect of CYP, GST, and SULT Polymorphisms and Their Interaction with Smoking on the Risk of Hepatocellular Carcinoma
Joint Authors
Grieco, Antonio
Boccia, Stefania
Turati, Federica
Arzani, Dario
Cefalo, Consuelo
Bulajic, Milutin
Pompili, Maurizio
Rapaccini, Gianlodovico
La Vecchia, Carlo
Panic, Nikola
Miele, Luca
Gasbarrini, Antonio
Amore, Rosarita
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
The aim of our study was to assess whether selected single nucleotide polymorphisms of CYP1A1 and 2E1, GSTM1, GSTT1, and SULT1A1 influence susceptibility towards HCC, considering their interaction with cigarette smoking.
Methods.
We recruited HCC cases and controls among patients admitted to the hospital “Agostino Gemelli,” from January 2005 until July 2010.
Odds ratios (OR) of HCC were derived from unconditional multiple logistic regression.
Gene-gene and gene-smoking interaction were quantified by computing the attributable proportion (AP) due to biological interaction.
Results.
The presence of any CYP2E1*5B variant allele (OR: 0.23; 95% CI: 0.06-0.71) and CYP2E1*6 variant allele (OR: 0.08; 95% CI: 0.01–0.33) was inversely related to HCC.
There was a borderline increased risk among carriers of combined CYP1A1*2A and SULT1A1 variant alleles (OR: 1.67; 95% CI: 0.97–3.24).
A significant biological interaction was observed between GSTT1 and smoking (AP = 0.48; 95% CI: 0.001–0.815), with an OR of 3.13 (95% CI: 1.69–5.82), and borderline significant interaction was observed for SULT1A1 and smoking (AP = 0.36; 95% CI: −0.021–0.747), with an OR of 3.05 (95% CI: 1.73–5.40).
Conclusion.
CYP2E1*5B and CYP2E1*6 polymorphisms have a favourable effect on the development of HCC, while polymorphisms of GSTT1 and SULT1A1 might play role in increasing the susceptibility among smokers.
American Psychological Association (APA)
Boccia, Stefania& Miele, Luca& Panic, Nikola& Turati, Federica& Arzani, Dario& Cefalo, Consuelo…[et al.]. 2015. The Effect of CYP, GST, and SULT Polymorphisms and Their Interaction with Smoking on the Risk of Hepatocellular Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054520
Modern Language Association (MLA)
Boccia, Stefania…[et al.]. The Effect of CYP, GST, and SULT Polymorphisms and Their Interaction with Smoking on the Risk of Hepatocellular Carcinoma. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054520
American Medical Association (AMA)
Boccia, Stefania& Miele, Luca& Panic, Nikola& Turati, Federica& Arzani, Dario& Cefalo, Consuelo…[et al.]. The Effect of CYP, GST, and SULT Polymorphisms and Their Interaction with Smoking on the Risk of Hepatocellular Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054520