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Evaluation of APP695 Transgenic Mice Bone Marrow Mesenchymal Stem Cells Neural Differentiation for Transplantation
Joint Authors
Zhang, John H.
Jia, Yanjie
Yang, Jun
Li, Qian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Even though there is a therapeutic potential to treat Alzheimer’s disease (AD) with neural cell replenishment and replacement, immunological rejections of stem cell transplantation remain a challenging risk.
Autologous stem cells from AD patients however may prove to be a promising candidate.
Therefore, we studied the neuronal differentiation efficiency of bone marrow mesenchymal stem cells (MSCs) from APP695 transgenic mice, which share features of human AD.
Method.
Cultured MSCs from APP695 transgenic mice are used; neuronal differentiation was assessed by immunocytochemistry and Western blot.
Correlation with Notch signaling was examined.
Autophage flux was assessed by western blot analysis.
Results.
MSCs from APP695 mice have higher neuronal differentiation efficiency than MSCs from wild type mice (WT MSCs).
The expression of Notch-1 signaling decreased during the differentiation process.
However, autophagy flux, which is essential for neuronal cell survival and neuronal function, was impaired in the neuronally differentiated counterparts of APP695 MSCs (APP695 MSCs–n).
Conclusion.
These results suggested autologous MSCs of APP690 mice may not be a good candidate for cell transplantation.
American Psychological Association (APA)
Li, Qian& Jia, Yanjie& Zhang, John H.& Yang, Jun. 2015. Evaluation of APP695 Transgenic Mice Bone Marrow Mesenchymal Stem Cells Neural Differentiation for Transplantation. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054526
Modern Language Association (MLA)
Li, Qian…[et al.]. Evaluation of APP695 Transgenic Mice Bone Marrow Mesenchymal Stem Cells Neural Differentiation for Transplantation. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054526
American Medical Association (AMA)
Li, Qian& Jia, Yanjie& Zhang, John H.& Yang, Jun. Evaluation of APP695 Transgenic Mice Bone Marrow Mesenchymal Stem Cells Neural Differentiation for Transplantation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054526