T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-Antitrypsin
Joint Authors
Baranovski, Boris M.
Freixo-Lima, Gabriella S.
Lewis, Eli C.
Rider, Peleg
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The traditional model of T helper differentiation describes the naïve T cell as choosing one of several subsets upon stimulation and an added reciprocal inhibition aimed at maintaining the chosen subset.
However, to date, evidence is mounting to support the presence of subset plasticity.
This is, presumably, aimed at fine-tuning adaptive immune responses according to local signals.
Reprograming of cell phenotype is made possible by changes in activation of master transcription factors, employing epigenetic modifications that preserve a flexible mode, permitting a shift between activation and silencing of genes.
The acute phase response represents an example of peripheral changes that are critical in modulating T cell responses.
α1-antitrypsin (AAT) belongs to the acute phase responses and has recently surfaced as a tolerogenic agent in the context of adaptive immune responses.
Nonetheless, AAT does not inhibit T cell responses, nor does it shutdown inflammation per se; rather, it appears that AAT targets non-T cell immunocytes towards changing the cytokine environment of T cells, thus promoting a regulatory T cell profile.
The present review focuses on this intriguing two-way communication between innate and adaptive entities, a crosstalk that holds important implications on potential therapies for a multitude of immune disorders.
American Psychological Association (APA)
Baranovski, Boris M.& Freixo-Lima, Gabriella S.& Lewis, Eli C.& Rider, Peleg. 2015. T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-Antitrypsin. BioMed Research International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054536
Modern Language Association (MLA)
Baranovski, Boris M.…[et al.]. T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-Antitrypsin. BioMed Research International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1054536
American Medical Association (AMA)
Baranovski, Boris M.& Freixo-Lima, Gabriella S.& Lewis, Eli C.& Rider, Peleg. T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-Antitrypsin. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1054536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054536