Identification, Characterization, and Developmental Expression Pattern of Type III Interferon Receptor Gene in the Chinese Goose
Joint Authors
Zhou, Qin
Chen, Shun
Qi, Yulin
Zhou, Hao
Wang, Mingshu
Jia, Renyong
Zhu, Dekang
Liu, Mafeng
Liu, Fei
Chen, Xiaoyue
Zhou, Xue
Cheng, Anchun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Interferons, as the first line of defense against the viral infection, play an important role in innate immune responses.
Type III interferon (IFN-λ) was a newly identified member of IFN family, which plays IFN-like antiviral activity.
Towards a better understanding of the type III interferon system in birds, type III interferon lambda receptor (IFNLR1) was first identified in the Chinese goose.
In this paper, we had cloned 1952 bp for goose IFNLR1 (goIFNLR1), including an ORF of 1539 bp, encoding a 512-amino acid protein with a 20 aa predict signal peptide at its N terminal and a 23 aa transmembrane region.
The predicted amino acid sequence of goIFNLR1 has 90%, 73%, and 34% identity with duck IFNLR1 (predicted sequence), chicken IFNLR1, and human IFNLR1, respectively.
And the age-related tissue distribution of goIFNLR1 was identified by Real Time quantitative PCR (RT-qPCR), we found that the goIFNLR1 has a mainly expression in epithelium-rich tissues similar to other species’, such as small intestinal, lung, liver, and stomach.
Moreover, a relatively high expression of goIFNLR1 was also observed in the secondary immune tissues (harderian gland and cecal tonsil).
The identification and tissue distribution of goIFNLR1 will facilitate further study of the role of IFN-λ in goose antiviral defense.
American Psychological Association (APA)
Zhou, Qin& Chen, Shun& Qi, Yulin& Zhou, Hao& Wang, Mingshu& Jia, Renyong…[et al.]. 2015. Identification, Characterization, and Developmental Expression Pattern of Type III Interferon Receptor Gene in the Chinese Goose. BioMed Research International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054548
Modern Language Association (MLA)
Zhou, Qin…[et al.]. Identification, Characterization, and Developmental Expression Pattern of Type III Interferon Receptor Gene in the Chinese Goose. BioMed Research International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1054548
American Medical Association (AMA)
Zhou, Qin& Chen, Shun& Qi, Yulin& Zhou, Hao& Wang, Mingshu& Jia, Renyong…[et al.]. Identification, Characterization, and Developmental Expression Pattern of Type III Interferon Receptor Gene in the Chinese Goose. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1054548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054548